Modulation of Hslo1 BK Channels by Aminoglycoside Antibiotics
نویسندگان
چکیده
constructed conductance-voltage plots from macroscopic current or measured NPo from single channel recordings. Ethanol-induced potentiation of cbv1 currents turned into inhibition as Cai increased, with a crossover at ~20 mM Cai. In contrast, slo2 and slo3 channels remained resistant to 50 mM ethanol even when probed at a wide concentration range of activating ion: 10-140 mMNai (slo2) and 0.01-10 mMOH i (slo3). Data underscore that the ethanol-sensitivity and its ligand-dependence found in slo1 channels are not extensive to other members of the slo channel family, suggesting selective interaction(s) between Ca2þ-sensing and ethanol-sensing mechanisms. Support: R37AA011560 (AMD)
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